Download A Systems Biology Approach to Blood by Seth Joel Corey, Marek Kimmel, Joshua N. Leonard PDF

By Seth Joel Corey, Marek Kimmel, Joshua N. Leonard

The blood method is multi-scale, from the organism to the organs to cells to intracellular signaling pathways to macromolecule interactions. Blood comprises circulating cells, mobile fragments (platelets and microparticles), and plasma macromolecules. Blood cells and their fragments end result from a highly-ordered method, hematopoiesis. Definitive hematopoiesis happens within the bone marrow, the place pluripotential stem cells supply upward thrust to a number of lineages of hugely really good cells. Highly-productive and consistently regenerative, hematopoiesis calls for a microenvironment of mesenchymal cells and blood vessels.

A platforms Biology method of Blood is split into 3 major sections: easy parts, physiological tactics, and scientific purposes. utilizing blood as a window, you'll be able to research healthiness and sickness via this distinctive device field with reactive organic fluids that mirrors the present hemodynamics of the vessel partitions and a number of the blood telephone varieties. Many blood ailments, infrequent and customary can and feature been exploited utilizing platforms biology methods with profitable effects and consequently perfect types for structures drugs. extra importantly, hematopoiesis bargains the best studied platforms with perception into stem phone biology, mobile interplay, improvement; linage programing and reprograming which are on a daily basis encouraged via the main mature and understood regulatory networks.

Show description

Read Online or Download A Systems Biology Approach to Blood PDF

Best biology books

Aestivation: Molecular and Physiological Aspects

A number of animal species dwell in environments characterised via a seasonal aid within the availability of water, which regularly yet no longer consistently happens while temperatures are optimum. for plenty of such animals, survival in the course of the hardest season calls for spending lengthy classes of time in a slightly inactive kingdom often called aestivation.

Biology of Inorganic Nitrogen and Sulfur

Nitrogen and sulfur compounds are consistently synthetized, degraded and switched over into other kinds in nature. there are lots of similarities within the precept difficulties and simple mechanisms of the biology of inorganic nitrogen and sulfur. Many info aren't but understood and therefore are the topic of lively research across the world.

Extra resources for A Systems Biology Approach to Blood

Example text

In our opinion, any promising approach towards a systemic understanding of stem cell organization (and that is what systems biology is all about) should consist of: (i) experimental systems that allow for controlled quantification of the effect of individual regulatory components including the possibility for targeted system perturbations (may be in an in vitro setting), (ii) a theoretical framework that allows for interpretation and for quantitative comparison of theoretical (model) predictions with experimental data, and last but not least, (iii) an experimental system that allows to validate the obtained result for the in vivo situation.

J Exp Med. 2011;208(2):251–60. 44. Winkler IG, Sims NA, Pettit AR, Barbier V, Nowlan B, Helwani F, et al. Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs. Blood. 2010;116(23):4815–28. 45. Broxmeyer HE. Chemokines in hematopoiesis. Curr Opin Hematol. 2008;15(1):49–58. 46. Lapidot T, Petit I. Current understanding of stem cell mobilization: the roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells. Exp Hematol.

2011;10(3):457–65. 71. Roeder I, Braesel K, Lorenz R, Loeffler M. Stem cell fate analysis revisited: interpretation of individual clone dynamics in the light of a new paradigm of stem cell organization. J Biomed Biotechnol. 2007;2007(3):84656. 72. Roeder I, Horn K, Sieburg HB, Cho R, Muller-Sieburg C, Loeffler M. Characterization and quantification of clonal heterogeneity among hematopoietic stem cells: a model-based approach. Blood. 2008;112(13):4874–83. 73. Roeder I, Horn M, Glauche I, Hochhaus A, Mueller MC, Loeffler M.

Download PDF sample

Rated 4.70 of 5 – based on 9 votes