By Anthony Koleske
Abl relations Kinases in improvement and illness presents an outline of the features of Abl relations kinases in improvement and sickness. This new name discusses the biochemical, genetic, and cellphone organic info that elucidate the mobile roles for those kinases in those approaches.
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Additional resources for Abl Family Kinases in Development and Disease (Molecular Biology Intelligence Unit)
Recent residts have identified four nuclear proteins, which when translocated to the cytoplasm, can activate mitochondria-dependent apoptosis.
Proc Natl Acad Sci USA 1999; 96(l6):9021-9026. 58. Plattner R, Irvin BJ, Guo S et al. A new link between the c-Abl tyrosine kinase and phosphoinositide signalling dirough PLC-gammal. Nat Cell Biol 2003; 5(4):309-319. 59. Clegg D O , Wingerd KL, Hikita ST et al. Integrins in the development, function and dysfunction of the nervous system. Front Biosci 2003; 8:d723-750. 60. Schaller M D . Paxillin: a focal adhesion-associated adaptor protein. Oncogene 2001; 20(44):6459-6472. 6 1 . Brown M C , Turner C E .
The N-terminal region of Abl resembles the Src-family of tyrosine kinases in that it contains the Src-homology (SH) 3, 2, and tyrosine kinase domains. These N-terminal domains assemble through intra-molecular interactions into an auto-inhibited conformation with low catalytic activity. The C-terminal region of Abl, not found in Src-family members, contains three nuclear localization signals (NLS), one nuclear export signal (NES), binding sites for G-actin and F-actin as well as binding site for double stranded A/T-rich DNA (Fig.