Download Alzheimer's Disease: Methods and Protocols (Methods in by N. M. Hooper PDF

By N. M. Hooper

A panel of hugely expert investigators describe intimately their cutting-edge biochemical, mobilephone organic, and molecular organic innovations for learning the molecular foundation of Alzheimer's affliction. those without difficulty reproducible, step by step tools specialize in paintings with the amyloid precursor protein and the amyloidogenic peptide A?, but additionally include-with the hot identity of presenilin proteins-techniques for picking out the constitution and organic functionality of those proteins. moreover, there are chapters masking the tau protein and its function in Alzheimer's illness, in addition to an introductory dialogue of the heritage of the sickness, its genetic foundation, and the at the moment to be had and attainable destiny healing brokers. state-of-the-art and extensive ranging, Alzheimer's illness: tools and Protocols presents prepared entry to confirmed, reproducible tools for elucidating the molecular foundation of this commonest senile dementia.

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19. , Spillantini, M. , Cairns, N. , and Crowther, R. A. (1992) Tau proteins of Alzheimer pairedhelical filaments: abnormal phosphorylation of all six brain isoforms. Neuron 8, 159-168. 20. Goedert, M. (1996) Tau protein and the neurofibrillary pathology of Alzheimer’s disease. Ann. NYAcad. Sci. 777, 121-131 21. , Trojanowski, J. , et al. (1994) Biopsy-derived adult human brain tau is phosphorylated at many of the same sites asAlzheimer’s disease paired helical filament tau. Neuron 13,989-1002.

28. Tang, M. , et al. (1998) The ApoE-&4allele and the risk of Alzheimer’s disease among African-Americans, whites and Hispanics. JAMA 279,751-755. 29. Farrer, L. , Cupples, L. , Myers, R. , van Duijn, C. , et al. (1998)Effects of age and ethnicity on the 1inkbetweenApolipopt E genotype and Alzheimer disease: a meta-analysis. JAMA 278,1349-1356. 30. Strittmatter,W. , Saunders,A. , Weisgraber, K. , Dong, L. ,et al. J. Biol. Chem. 270,9039-9042. 31. LaDu, M. , Falduto, M. , Manelli, A. , Reardon, C.

2. Functions and Pathogenesis of the Presenilins and Their Mutated Isoforms A potential clue to the functionof the presenilins comes from the recognition of strong homologyof PS 1 toCaenorrhabditis elegansproteins sel-12 and spe-4. PS-l shares 60% homology with sel-12 (66), which has been demonstrated to facilitate Lin- 12-mediated signaling. In mammals, lin- 12 homo are members of the Notch familyof receptors known as Notchl, Notch2, and Notch3. The molecular homology of both presenilins to sel-12 implies ainrole the signal transduction mechanisms mediatedby lin-l2/Notch, thus they may play a direct role in the cell fate decisions mediated by these same genes.

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