By Giovanni Luca Beretta, Franco Zunino (auth.), Karsten Krohn (eds.)
see desk of contents
Read or Download Anthracycline Chemistry and Biology II: Mode of Action, Clinical Aspects and New Drugs PDF
Best chemistry books
Mumtaz Virji: bits and bobs of Microbial Adhesion. - Martina Lahmann: Architectures of Multivalent Glycomimetics for Probing Carbohydrate-Lectin Interactions. - Stefan D. Knight and Julie Bouckaert: constitution, functionality, and meeting of kind 1 Fimbriae. - Knut Ohlsen, Tobias A. Oelschlaeger, Jörg Hacker, A.
Twenty-three conscientiously chosen, peer-reviewed contributions from the overseas convention on natural and utilized Chemistry (ICPAC 2014) are featured during this edited e-book of complaints. ICPAC 2014, a biennial assembly, used to be held in Mauritius in June 2014. The topic of the convention used to be “Crystallizing principles: The function of Chemistry” and it matched the announcement of the yr 2014 because the overseas yr of Crystallography.
- High Performance Polymers - Polyimides Based - From Chemistry to Applications
- Bonds between atoms
- Receptor Chemistry towards the Third Millennium, Proceedings of the 12th Camerino-Noordwijkerhout Symposium
- The Leukotrienes. Chemistry and Biology
- Selective Oxidation Processes
Extra resources for Anthracycline Chemistry and Biology II: Mode of Action, Clinical Aspects and New Drugs
A One-electron quinone reduction; B Two-electron side chain carbonyl reduction; C One electron hydroquinone oxidation. 2 Two-Electron Reductive Bioactivation Anthracyclines are said to gain toxicity also after a two-electron reduction of the side chain C-13 carbonyl moiety. In laboratory animals such reaction is mediated by heterogeneous families of cytoplasmic NADPHdependent aldo/keto- or carbonyl-reductases, but in human myocardial samples it seems to be mediated almost exclusively by a speciﬁc family of aldehyde reductases [26, 27].
Menna et al. the summation of injuries inﬂicted by de novo DOX and long-lived cardiac residues of prior DOX. Retrospective clinical studies have also shown that the severity of cardiac damage in a given patient is inversely correlated to the levels of P glycoprotein (Pgp) in the endothelium of arterioles and capillaries of the heart of that patient . Pgp is a prominent member of the superfamily of ATPbinding proteins that extrude anthracyclines and many other drugs from within the cells into the extracellular ﬂuids.
One-Electron Oxidative Degradation and Detoxiﬁcation . . . . . . . . . . . . . . . . . . . . . . 4 Translating the Metabolic Determinants of Cardiotoxicity into Protective Strategies Antioxidants . . . . . . . . . Iron Chelators . . . . . . . . Noncardiotoxic Anthracycline Analogs . Modulators of Anthracycline Degradation . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Cardiotoxic Synergism of Anthracyclines with Other Drugs .