By Jacqueline A. Hubbard, Devin K. Binder
Epilepsy is a devastating team of neurological issues characterised by means of periodic and unpredictable seizure task within the brain. there's a severe desire for brand spanking new medicines and ways given than at the very least one-third of all epilepsy sufferers usually are not made freed from seizures through latest medicinal drugs and turn into "medically refractory". a lot of epilepsy examine has thinking about neuronal healing goals, yet present antiepileptic medicinal drugs usually reason serious cognitive, developmental, and behavioral unintended effects. fresh findings point out a serious contribution of astrocytes, star-shaped glial cells within the mind, to neuronal and community excitability and seizure activity. in addition, many vital mobile and molecular adjustments happen in astrocytes in epileptic tissue in either people and animal types of epilepsy. The objective of Astrocytes and Epilepsy is to comprehensively overview intriguing findings linking adjustments in astrocytes to useful adjustments accountable for epilepsy for the 1st time in publication format. those insights into astrocyte contribution to seizure susceptibility point out that astrocytes may well symbolize an immense new healing objective within the keep an eye on of epilepsy.
Astrocytes and Epilepsy contains heritage explanatory textual content on astrocyte morphology and body structure, epilepsy versions and syndromes, and facts from either human tissue stories and animal types linking practical alterations in astrocytes to epilepsy. fantastically labelled diagrams are awarded and proper figures from the literature are reproduced to clarify key findings and ideas during this speedily rising field. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators in addition to neurologists and different experts taking good care of sufferers with epilepsy.
- Presents the 1st accomplished e-book to synthesize ancient and up to date examine on astrocytes and epilepsy into one coherent volume
- Provides an exceptional source at the box of astrocyte biology and astrocyte-neuron interactions
- Details strength healing ambitions, together with chapters on hole junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation
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Additional info for Astrocytes and Epilepsy
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