Download Astrocytes and Epilepsy by Jacqueline A. Hubbard, Devin K. Binder PDF

By Jacqueline A. Hubbard, Devin K. Binder

Epilepsy is a devastating team of neurological issues characterised by means of periodic and unpredictable seizure task within the brain.  there's a severe desire for brand spanking new medicines and ways given than at the very least one-third of all epilepsy sufferers usually are not made freed from seizures through latest medicinal drugs and turn into "medically refractory".  a lot of epilepsy examine has thinking about neuronal healing goals, yet present antiepileptic medicinal drugs usually reason serious cognitive, developmental, and behavioral unintended effects. fresh findings point out a serious contribution of astrocytes, star-shaped glial cells within the mind, to neuronal and community excitability and seizure activity.  in addition, many vital mobile and molecular adjustments happen in astrocytes in epileptic tissue in either people and animal types of epilepsy.  The objective of Astrocytes and Epilepsy is to comprehensively overview intriguing findings linking adjustments in astrocytes to useful adjustments accountable for epilepsy for the 1st time in publication format.  those insights into astrocyte contribution to seizure susceptibility point out that astrocytes may well symbolize an immense new healing objective within the keep an eye on of epilepsy. 

Astrocytes and Epilepsy contains heritage explanatory textual content on astrocyte morphology and body structure, epilepsy versions and syndromes, and facts from either human tissue stories and animal types linking practical alterations in astrocytes to epilepsy.  fantastically labelled diagrams are awarded and proper figures from the literature are reproduced to clarify key findings and ideas during this speedily rising field.  Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators in addition to neurologists and different experts taking good care of sufferers with epilepsy.

  • Presents the 1st accomplished e-book to synthesize ancient and up to date examine on astrocytes and epilepsy into one coherent volume
  • Provides an exceptional source at the box of astrocyte biology and astrocyte-neuron interactions
  • Details strength healing ambitions, together with chapters on hole junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation

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In: Costa E, Cote LJ, Yahr MD, editors. Biochemistry and pharmacology of the basal ganglia. New York: Raven Press; 1966. p. 195–204. [121] Hertz L, Hansson E, Rönnbäck L. Signaling and gene expression in the neuron-glia unit during brain function and dysfunction: Holger Hydén in memoriam. Neurochem Int 2001;39(3):227–52. [122] Hydén H. The effect of tranylcypromine on synthesis of macromolecules and enzyme activities in neurons and glia. Neurology 1968;18:732–6. [123] Kuffler WS, Potter DD. Glia in the leech central nervous system: physiological properties and neuron-glia relationship.

Kornfield; 1893. [57] Andriezen WL. The neuroglia elements of the brain. Br Med J 1893;2:227–30. [58] Schleich CL. Schmerzlose Operationen. Oertliche Betäubung mit indiffrenten Flüssigkeiten. Berlin: Julius Springer; 1894. [59] Lugaro E. Sulle funzioni della nevroglia. Riv Patol Nerv Ment 1907;12:225–33. [60] Mennerick S, Zorumski CF. Glial contributions to excitatory neurotransmission in cultured hippocampal cells. Nature 1994 Mar 3;368(6466):59–62. [61] Danbolt NC. Glutamate uptake. Prog Neurobiol 2001;65(1):1–105.

El tercer elemento de los centros nerviosos. Bol Soc Esp Biol 1919;9:69–120. [56] Lenhossék Mv. Der feinere Bau des Nervensystems im Lichte neuester Forschung. Berlin: Fisher’s Medicinische Buchhandlung H. Kornfield; 1893. [57] Andriezen WL. The neuroglia elements of the brain. Br Med J 1893;2:227–30. [58] Schleich CL. Schmerzlose Operationen. Oertliche Betäubung mit indiffrenten Flüssigkeiten. Berlin: Julius Springer; 1894. [59] Lugaro E. Sulle funzioni della nevroglia. Riv Patol Nerv Ment 1907;12:225–33.

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