By Ronald van Vollenhoven
This e-book offers a complete review of the to be had biologic treatments when evaluating them to plain disorder editing anti-rheumatic medicines, and discusses how top to figure out which treatment is fabulous for anyone sufferer within the framework of present instructions. Biologics for the therapy of Rheumatoid Arthritis is an up to date and concise sensible advisor to the newest healing advancements during this box. This ebook is a useful resource of topical details for all rheumatologists and healthiness care execs treating sufferers with rheumatoid arthritis.
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Extra resources for Biologics for the Treatment of Rheumatoid Arthritis
Currently available tumor necrosis factor inhibitor therapies Adalimumab Adalimumab (Humira) was originally developed in the 1990s at the German pharmaceutical company Knoll with the designation D2E7. Whereas most therapeutic monoclonal antibodies had originally been generated in mice and subsequently grafted onto a human immunoglobulin framework, resulting in a chimeric monoclonal antibody molecule, D2E7 was the result of a novel process based on recombinant DNA technology where human genes coding for antibody chains were generated through phage-display, selected, and recombined so as to achieve specific TNF-binding while remaining fully human.
Adalimumab added to a treat-to-target strategy with methotrexate and intra-articular triamcinolone in early rheumatoid arthritis increased remission rates, function and quality of life. The OPERA Study: an investigatorinitiated, randomised, double-blind, parallel-group, placebo-controlled trial. Ann Rheum Dis. 2014;73:654-661. Cronstein BN, Eberle MA, Gruber HE, Levin RI. Methotrexate inhibits neutrophil function by stimulating adenosine release from connective tissue cells. Proc Natl Acad Sci USA.
Horslev-Petersen K, Hetland ML, Junker P, et al. Adalimumab added to a treat-to-target strategy with methotrexate and intra-articular triamcinolone in early rheumatoid arthritis increased remission rates, function and quality of life. The OPERA Study: an investigatorinitiated, randomised, double-blind, parallel-group, placebo-controlled trial. Ann Rheum Dis. 2014;73:654-661. Cronstein BN, Eberle MA, Gruber HE, Levin RI. Methotrexate inhibits neutrophil function by stimulating adenosine release from connective tissue cells.