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By John B. Lloyd (auth.), John B. Lloyd, Robert W. Mason (eds.)

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`The heterogeneity of very formidable, and the result's, total, winning as a result top of the range of the person contributions...highly recommended.'
Amercian Scientist.

`Well written and timely...of curiosity to all these desirous about the examine of this organelle and for these attracted to the clinical and genetic facets of lysosomal disorders...recommended.'
Journal of scientific Genetics

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Extra resources for Biology of the Lysosome

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Chen et ai. (1993) have reported that there is a casein kinase II phosphorylation site proximal to the dileucine motif of MPR 300 (Ser 156; at position 2492) that is part of the sorting signal. , 1990). It was proposed that phosphorylation of both sites occurs in or shortly after the receptor exits the TGN (Meresse and Hoflack, 1993). , 1993). These data suggest that phosphorylation of the MPR 300 cytoplasmic domain is an early event, facilitating the restricted localization of AP-l adaptor molecules and the proper interaction with components required for efficient lysosomal enzyme sorting (see Section 5).

Trans. 23:IS. Trowbridge, I. , Collawn, J. E, and Hopkins, C. , 1993, Signal-dependent membrane protein trafficking in the endocytic pathway, Annu. Rev. Cell Bioi. 9:129-161. Vadgama, 1. , Kopple, J. , and Jonas, A. , 1991, Characteristics of taurine transport in rat liver Iysosomes, J. Cell. Physio/. 147:447-454. Chapter 2 Origin of Lysosomal Proteins Thomas Braulke 1. INTRODUCTION Lysosomes are the major intracellular site for the degradation of a variety of macromolecules, including proteins, carbohydrates, nucleic acids, and lipids, that are internalized from the extracellular space by endocytosis, delivered by fusion with phagosomes, or derived from the biosynthetic pathway.

1990). , 1993).

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