Download Bone Disorders : Biology, Diagnosis, Prevention, Therapy by Reiner Bartl, Christoph Bartl PDF

By Reiner Bartl, Christoph Bartl

This accomplished consultant covers the research, prognosis, prevention, and remedy of all of the bone issues encountered in scientific perform. Written in an easy-to-read sort, it updates physicians at the present wisdom of bone constitution, body structure, and pathology, with emphasis at the analysis and therapy of universal bone illnesses. this present day, either clinical practitioners and experts desire easy accessibility to info on “bone difficulties” with a purpose to support sufferers and their households. as a result this publication offers with every little thing from the fundamental body structure of bone and mineral metabolism to the software of radiologic imaging and really good exams in bone analysis and present therapy ideas. it's scientifically dependent yet presents transparent directions for coping with bone difficulties and for lifelong upkeep of skeletal constitution and serve as. it's going to support not just within the supply of powerful therapy but in addition in illness prevention.

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Extra info for Bone Disorders : Biology, Diagnosis, Prevention, Therapy

Sample text

This negative “bone balance” has three possible causes: • Increased osteoclastic activity without increased osteoblastic activity (“high turnover”) • Normal osteoclastic but decreased osteoblastic activity (“low turnover”) • Decreased osteoclastic and osteoblastic activity (“atrophic” or “adynamic” bone) Consequently an overall decrease in the bone correlates primarily with the number of BRU and with the lack of coordination between the cells of the BRU. The level of excretion of calcium and collagen metabolites in the urine reflects the degree of resorption of the bone.

In fact, OPG could represent the long sought-after molecular link between arterial calcification and bone resorption. This link underlies the clinical coincidence of vascular disease and osteoporosis, an association most frequent in postmenopausal women and in elderly people. OPG could represent a novel pathway for possible therapeutic manipulation of bone remodelling. Specific aspects of remodelling involve specific factors, as for example, the impact of VEGF (vascular endothelial growth factor) in angiogenesis and endochondral bone formation, in ossification of mandibular condyles and in the growth of the long bones.

On completion of the bone remodelling cycle, a phase of secondary mineralisation begins. This process consists of a gradual maturation of the mineral component, including an increase in the amount of crystals and/or an augmentation of crystal size towards its maximum dimension. 1 Function of the Skeleton 15 Fig. 6 Flat osteoblasts and layers of newly formed osteoid (various shades of red) on mineralised bone (blue). Ladewig staining Fig. 7 Structure of bone: periosteum and cortical bone together with their vascular and nervous system surround the trabecular network matrix.

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