Download Breast Epithelial Antigens: Molecular Biology to Clinical by D. H. Wreschner, I. Tsarfaty, M. Hareuveni, J. Zaretsky, N. PDF

By D. H. Wreschner, I. Tsarfaty, M. Hareuveni, J. Zaretsky, N. I. Smorodinsky, S. Zrihan (auth.), Roberto L. Ceriani (eds.)

The wealth of analysis leads to the realm of breast melanoma prognosis and remedy with monoclonal antibodies offered in prior workshops is now complemented with a brand new rendition of the court cases of the 4th Workshop on Monoclonal Antibodies and Breast melanoma. held in San Francisco on November 5-6. 1990. easy technology findings suggested in earlier workshops have now percolated to the medical point and became immunoassays and imaging and treatment reagents. because the application indicates us. hence. the most recent discoveries in immunology. biochemistry and molecular biology of breast epithelial antigens and their corresponding antibodies have produced more moderen diagnostic exams and healing techniques which are changing and bettering the way in which we assault breast melanoma. the hot amazing and quick developments within the molecular biology of numerous of the breast epithelial antigens are offered during this quantity. the best way the ultimate meeting of other parts of the breast antigens is accomplished and their capabilities are actually inside of our grab because of new realizing of molecular constitution of those breast antigens. moreover. more recent immunoassays aiming on the earliest detection of the affliction also are defined that combine with promising makes an attempt at imaging and radioimmunotherapy to set the level for brand spanking new oncological percentages in breast melanoma therapy. these kind of parts of extreme involvement of scientists with diversified specialties are offered during this quantity. which proves the necessity for multidisciplinary techniques to extend our possibilities for achievement during this box of clinical research.

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Coli. Cloning of a cDNA Encoding a 70KDa Antigen in HMFG A cocktail of Mc13 and McR2 was used to immunoscreen a ~gtll eDNA expression library prepared from human breast tissue (C10ntech, Palo Alto, CAl. There were 3 out of about 900,000 positive phage plaques, one of which bound both monoclonal Abs and was further characterized. The sequence of a 297 bp cDNA, BA70-1, which we have previously described 2 , was used to design oligonucleotide primers for anchor PCR3. Two DNA fragments that extended the BA70 sequence in the 3' direction were obtained that were approximately 400 and 800 base pairs long.

The molecule may have a protective function in normal tissues. Episialin is normally expressed at the apical surface but in carcinoma cells polarisation is often lost which results in the presence of episialin at the plasma membrane facing the stroma or adjacent cells. Moreover, there is evidence that in carcinoma cells the expression of episialin is increased. Overexpression of this rigid and strongly negatively charged molecule (due to the abundance of sialic acid residues on the glycosidic side chains) may have a strong destabilizing influence on cell-substratum and cell-cell interactions including intercellular adhesion.

Nature 328, 82-84. A. Peterson, J. Arklie, J. L. F. Bodmer (1981). Monoclonal antibodies to epithelium specific components of the human milkfat globule membrane: Production and reaction with cells in culture. Int. J. Cancer 28, 17-21. Williams, C. , Wreschner, D. S. (1990). Multiple protein forms of the human breast tumorassociated epithelial membrane antigen (EMA) are generated by alternative splicing and induced by hormonal stimulation. Biochem. Biophys. Res. Comm. 170, 1331-1338. , M. Hareuveni, I.

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