By Susanne Grässel, Attila Aszódi
In 3 Volumes this mini ebook sequence offers present wisdom and new views on cartilage as a really good but flexible tissue. this primary quantity offers a accomplished evaluation at the uncomplicated composition and improvement of cartilaginous tissues by means of the outline of the most important signaling pathways which control cartilage morphogenesis and function.
This publication addresses Professors, researchers and PhD scholars who're drawn to musculoskeletal and cartilage biology.
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Extra info for Cartilage: Volume 1: Physiology and Development
It will be interesting to investigate from this point of view biological suprastructures such as chromatin, transcriptional machineries, the various forms of the cytoskeleton, ribosomes, proteasomes, multienzyme complexes, or lipid rafts. Just over 100 different human COL2A1 mutations have been described and are listed in the Cardiff University Human Gene Mutation Database (http://www. org). Work with transgenic mouse models confirmed the importance of collagen II for endochondral ossification during embryonal skeletogenesis and its role in the pathology of heritable skeletal disorders (for review, see Aszodi et al.
Proc Natl Acad Sci U S A 101(44):15633–15638 Sjöberg A, Önnerfjord P, Mörgelin M, Heinegård D, Blom AM (2005) The extracellular matrix and inflammation: fibromodulin activates the classical pathway of complement by directly binding C1q. J Biol Chem 280(37):32301–32308. M504828200 [pii]. 1074/jbc. M504828200 Sjöberg AP, Manderson GA, Mörgelin M, Day AJ, Heinegård D, Blom AM (2009) Short leucinerich glycoproteins of the extracellular matrix display diverse patterns of complement interaction and activation.
This defect is associated with the inability to develop intervertebral disks (IVDs) (Aszodi et al. 1998a). Previous studies showed that in both Col2a1-null mice and in a patient with achondrogenesis type II carrying a COL2A1 mutation collagen II is completely absent in the cartilage, whereas collagen I was found to be ectopically expressed in the cartilage (Aszodi et al. 1998a; Chan et al. 1995). Recently, it was demonstrated that chondrocytes after collagen II knockdown via siRNA synthesized a substantial amount of collagen I.