Download Cell Biology of Extracellular Matrix: Second Edition by Elizabeth D. Hay (auth.), Elizabeth D. Hay (eds.) PDF

By Elizabeth D. Hay (auth.), Elizabeth D. Hay (eds.)

In the ten-year period because the first variation of this quantity went to press, our wisdom of extracellular matrix (ECM) functionality and constitution has enor­ mously elevated. Extracellular matrix and cell-matrix interplay at the moment are regimen issues within the conferences and annual stories backed by means of mobile biology societies. learn in molecular biology has so complicated the variety of identified matrix molecules and the subject of gene constitution and law that we gained­ dered how most sensible to include the recent fabric. for instance, we deliberated over the inclusion of chapters on molecular genetics. We made up our minds that with really appropriate enhancing shall we current the new findings in molecular biology in the similar cellphone biology framework that used to be used for the 1st version, utilizing 3 vast headings: what's extracellular matrix, how is it made, and what does it do for cells? keeping keep watch over over the evaluation of literature almost about ECM was once now not continually a simple job, yet we felt it used to be necessary to creation of a hugely readable quantity, one compact sufficient to serve the the scholar as an advent and the investigator as a brief replace on graduate the real contemporary discoveries. the 1st version of this quantity loved con­ desire the reader reveals this variation both invaluable. siderable good fortune; we D. Hay Elizabeth vii Contents Introductory feedback 1 Elizabeth D. Hay half I. what's EXTRACELLULAR MATRIX? bankruptcy 1 Collagen T. F. Linsenmayer 1. advent . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 2. The Collagen Molecule . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . eight 2. 1. Triple-Helical Domain(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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145-172, Academic Press, New York. Burgeson, R. K, Lunstrum, G. , Rimberg, C. , Rosenbaum, L. , and Keene, D. , 1990, The structure and function of type VII collagen, Ann. Y. Acad. Sci. 580:32-43.

1988, Cloning and sequencing of pro-alpha 1 (XI) collagen cDNA demonstrates that type XI belongs to the fibrillar class of collagens and reveals that the expression of the gene is not restricted to cartilagenous tissue, J. BioI. Chern. 263:17159-17166. Birk, D. K, Fitch, J. , Babiarz, J. , and Linsenmayer, T. , 1988, Collagen type I and type V are present in the same fibril in the avian corneal stroma, J. Cell BioI. 106:999-1008. Birk, D. K, Fitch, J. , Babiarz, J. , Doane, K. , and Linsenmayer, T.

These type VI structures, as found within tissues in situ (Fig. 1-10), consist of alternating filamentous regions (65-75 nm long) and beaded regions (42-44 nm long), thus giving rise to the term beaded filaments. This periodicity is difficult to discern by routine electron microscopy, as are the beaded filaments themselves. However they can be readily visualized in tissues treated with ATP to produce SLS-type aggregates (Bruns, 1984), or by immunoelectron microscopy with monoclonal antibodies (Fig.

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