Download Cholestatic Liver Disease (Clinical Gastroenterology) by Keith D. Lindor, Jayant A. Talwalkar PDF

By Keith D. Lindor, Jayant A. Talwalkar

During the last 20 years, there was a gentle elevate in wisdom linked to the medical manifestations of cholestatic liver sickness. in keeping with those medical occasions, this e-book offers valuable and well timed info at the ever-expanding topic of cholestatic liver illness. It provides clinical updates from major specialists which relate to the medical evaluate and administration of cholestatic liver problems.

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Additional resources for Cholestatic Liver Disease (Clinical Gastroenterology)

Example text

Drug- I nduced Sclerosing Cholangitis Strictures in the intra- and extrahepatic bile ducts have been described after the intra-arterial injection of chemotherapeutic agents into the liver. These strictures develop in more than half of patients treated with floxuridine, a drug that is used for hepatic metastases from carcinoid and colon cancer (37). The hepatic duct and the confluence of the right and left hepatic ducts are the most common sites for stricture development. The pathologic mechanism is thought to be related to arterial ischemia, and jaundice usually occurs 3- 6 mo after administration of the medication (38).

J eH patol 2003; 39: 62-67. 80. Bergasa NV. The pruritus of cholestasis. J Hepatol2005; 34 : 1078-1088. 81. Raiford DS. Pruritus of chronic cholestasis. QJM 1995; 88: 603-607. 82. Smith A L , Ignacio R J , Winesett MP, et al. Vanishing bile duct syndrome: amoxicillin-clavulanic acid associated intra-hepatic cholestasis responsive to ursodeoxycholic acid. J Pediatr Gastroenterol Nutr 2005; 14 : 64 9-74 3. 83. O'Brien CB, Shields DS, Saul SH, and Reddy R K . Drug-induced vanishing bile duct syndrome: response to ursodiol.

11. Lycopodium Serratum (Jin Bu uH an) iJ n Bu Huan has been used for centuries in China as an antispasmodic, analgesic, and sedative. Much controversy surrounded this herb when a report of three cases of acute hepatitis caused by the herb was published in 1994 (72). The liver biopsy of one of the patients revealed dense periportal eosinophils, suggesting a hypersensitivity reaction. The readministration of Jin Bu Huan in two of the patients caused abrupt recurrence of symptoms. Eleven other cases of iJ n Bu Huan induced hepatitis have since been reported, and four of these had a presentation consistent with cholestatic disease (13).

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