By Colin G. Miller, Derek Pearson (auth.), Dr Derek Pearson BSc, PhD, Dr Colin G. Miller BSc, PhD (eds.)
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Extra resources for Clinical Trials in Osteoporosis
Generally, results of such tests should not be fed back to the patient as genetic testing in osteoporosis is speculative and non-specific at present. If there is feedback, it is unlikely that there will be any genetic counseling required, but investigators may want to consider how to approach other family members if the study is to be widened. Now that specific cell lines are the subject of patents this is clearly a sensitive area. Trial subjects may need to be made aware of the transfer of samples to external organizations for genetic testing, particularly those that may develop patents commercially.
27. 28. 29. 30. 31. 23 Ettinger B, Pressman A, Silver P. Effect of age on reasons for initiation and discontinuation of hormone replacement therapy. Menopause 1999;6:282-9. Faulkner DL, Young C, Hutchins D, McCollam JS. Patient noncompliance with hormone replacement therapy: a nationwide estimate using a large prescription claims database. Menopause 1998;5:226-9. Vestergaard P, Hermann AP, Gram J et al. Improving compliance with hormonal replacement therapy in primary osteoporosis prevention. Maturitas 1997;28:137-45.
Recommendations of the International Commission on Radiation Protection, ICRP Publication 60, Ann ICRP 1991;21:1-77. 14. Radiation Protection 99. Guidance on medical exposures in medical and biomedical research. European Commission. Luxembourg: Office for Official Publications of the European Communities, 1998. 15. Protection of human subjects; Belmont Report: notice of report for public comment. Federal Register 1979;44:23191-7. htm) 16. 20 General requirements for informed consent. html) 17. Kent G.