By Kenneth D. Karlin, Shinobu Itoh, Steven Rokita
Covers the drastically increasing topic of oxidative techniques mediated via copper ions inside of organic systems
Copper-mediated organic oxidations provide a huge diversity of essentially very important and possibly sensible chemical methods that pass many chemical and pharmaceutical disciplines. This most up-to-date quantity within the Wiley Series on Reactive Intermediates in Chemistry and Biology is split into 3 logical components in the subject of copper/oxygen chemistry— organic structures, conception, and bioinorganic types and applications—to discover the biosphere for its hugely developed and hence effective oxidative variations within the discovery of latest different types of interactions among molecular oxygen and copper ion. that includes a various choice of subject material unified in a single whole and accomplished source, Copper-Oxygen Chemistry probes the elemental facets of copper coordination chemistry, artificial natural chemistry, and organic chemistry to bare either the organic and chemical elements using the present interesting study efforts in the back of copper-oxygen chemistry. moreover, Copper-Oxygen Chemistry:
Addresses the considerably expanding literature on oxygen-atom insertion and carbon-carbon bond-forming reactions in addition to enantioselective oxidation chemistries
Progresses from organic structures to spectroscopy and thought, and onward to bioinorganic versions and applications
Covers a wide range of response kinds resembling insertion and dehydrogenation reactions that make the most of the inexpensive, plentiful, and energy-containing O2 molecule
With thorough insurance via fashionable authors and researchers shaping techniques during this growing to be box, this precious reference is vital examining for bioinorganic chemists, in addition to natural, artificial, and pharmaceutical chemists in academia and undefined.
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Extra resources for Copper-Oxygen Chemistry (Wiley Series of Reactive Intermediates in Chemistry and Biology)
2006, 106, 3095–3118. 1. INTRODUCTION Dioxygen (O2) is an essential element for life. , amino acids, lipids, Copper-Oxygen Chemistry, First Edition. Edited by Kenneth D. Karlin and Shinobu Itoh. Ó 2011 John Wiley & Sons, Inc. Published 2011 by John Wiley & Sons, Inc. 23 24 COPPER DIOXYGENASES sugars, vitamins, hormones, and various poisons). The metabolism generates energy and controls vital functions. However, owing to its triplet ground state, O2 cannot directly react with singlet ground-state substrates to produce singlet-state products because that would imply a violation of the conservation of the total angular momentum.
16. Klinman, J. ; Edmondson, D. E. Evidence for two copper atoms/subunit in dopamine beta-monooxygenase catalysis J. Biol. Chem. 1984, 259, 3399–3402. 17. ; Ljones, T. Direct spectrophotometric detection of ascorbate free radical formed by dopamine b-monooxygenase and by ascorbate oxidase Biochim. Biophys. Acta 1980, 630, 30–35. 18. Diliberto, E. ; Allen, P. L. Mechanism of dopamine-b-hydroxylation. Semidehydroascorbate as the enzymic oxidation product of ascorbate J. Biol. Chem. 1981, 256, 3385–3393.
J. The copper centers of tyramine b-monooxygenase and its catalytic-site methionine variants. An x-ray absorption study. J. Biol. Inorg. Chem. 2010, 15, 1195–1207. 30. Fitzpatrick, P. ; Villafranca, J. J. Mechanism-based inhibitors of dopamine betahydroxylase containing acetylenic or cyclopropyl groups J. Am. Chem. Soc. 1985, 107, 5022–5023. 31. Fitzpatrick, P. ; Flory, D. ; Villafranca, J. J. 3-Phenylpropenes as mechanism-based inhibitors of dopamine beta-hydroxylase: Evidence for a radical mechanism Biochemistry 1985, 24, 2108–2114.