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By James M. Ostell (auth.), Olivier Bodenreider, Bastien Rance (eds.)

This booklet constitutes the refereed complaints of the eighth overseas convention on facts Integration within the existence Sciences, DILS 2012, held in university Park, MD, united states, on June 28-29, 2012. The eleven revised papers integrated during this quantity have been conscientiously reviewed and chosen. The papers hide the subsequent subject matters: foundations of knowledge integration, new paradigms for information integration, and integrating medical data.

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Extra resources for Data Integration in the Life Sciences: 8th International Conference, DILS 2012, College Park, MD, USA, June 28-29, 2012. Proceedings

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Only node pairs that are in a specific relationship are considered for distance computation. The current version of PAnG [1] uses the simple shortest path length between a pair of terms as the distance metric. In this paper, we evaluate more sophisticated distance metrics in Section 4. 2 Graph Summarization PAnG generates graph summaries for representing patterns. A summary of a tripartite annotation graph is also a graph. While there are many methods to summarize graphs, we focus on the graph summarization (GS) approach of [15].

We recognize that our goals are ambitious and that we have to solve numerous challenges. First, we have to find patterns in annotation graph datasets. On this challenge, we can report some initial success [1,22,27]. Next, we must integrate annotation data across multiple organisms to perform comparative genomics. We must identify a protocol and efficient processes to obtain orthologs or other matching genes from multiple organisms. Potential resources and tools include the Homologene service from NCBI [9], Inparanoid [10], a database that includes animals, and Plaza [18], which is exclusive to plant species.

In: IJCAI, pp. 448–453 (1995) 21. : The Arabidopsis Information Resource (TAIR): a model organism database providing a centralized, curated gateway to arabidopsis biology, research materials and community. Nucleic Acids Res. 31(1), 224–228 (2003) 22. : Dense Subgraphs with Restrictions and Applications to Gene Annotation Graphs. In: Berger, B. ) RECOMB 2010. LNCS, vol. 6044, pp. 456–472. Springer, Heidelberg (2010) 23. : Go and po annotations for cation/h+ exchangers. Personal Communication (2011) 24.

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