By Henk C. van der Plas (Eds.)
Demonstrated in 1960, Advances in Heterocyclic Chemistry is the definitive serial within the area--one of significant value to natural chemists, polymer chemists, and lots of organic scientists. Written through validated specialists within the box, the great experiences mix descriptive chemistry and mechanistic perception to yield an knowing of the way the chemistry drives the houses. Degenerate ring changes of heterocycles are categorised as reactions within which a heterocyclic method is switched over into an identical heterocyclic approach. This monograph covers an authoritative, finished review of a number of degenerate ring modifications in 5- and 6-membered heterocycles. It exhibits how by way of
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Extra info for Degenerate Ring Transformations of Heterocyclic Compounds
9). 9 SN(ANRORC) REACTIONS IN AZINES 19 2. ISOQUINOLINES Amination of 3-bromoisoquinoline with potassium amide/liquid ammonia involves (in contrast to the amination of 2-bromopyridine, see Section II,B,1) an ANRORC process. , formation of 3-amino[15N]isoquinoline (13) (74RTC198). , ortho-iminomethylenebenzylcyanide (12), are involved in the formation of 3aminoisoquinoline (14). It can be suggested that the ratio 55 : 45 for the distribution of the 15N label over the exocyclic as well as ring nitrogen in 3-aminoisoquinoline may due to the occurrence of a scrambling process, taking place in the ring-labeled 13.
The facile ring opening of the pyrimidine ring in 66 is not unexpected. 33 adduct a 6-amino-1,6-dihydropyrimidine derivative (74RTC114) (see Chapter III). Amination of 4-phenylpyrimidine under more classical conditions (potassium amide, solvent m-xylene, 90°C) also affords a mixture of the 6amino-4-phenylpyrimidine (35%) and 2-amino-4-phenylpyrimidine (55%). e. formation of 60 and 61, proving that under these reaction conditions the SN(ANRORC) mechanism plays only a very minor role in the amination.
This result is in striking contrast with the behavior observed in the aminodehydrogenation reaction of 4-phenyl- and 5phenylpyrimidine. This result seems to indicate that the -adducts are rather stable in the liquid ammonia containing potassium amide and not inclined to ring opening. It has been reported (39JPJ18) that the Chichibabin amination of 4methylpyrimidine, using sodium amide in boiling decaline, affords a mixture of 2-amino-4-methylpyrimidine and 2,6-diamino-4-methylpyrimidine. In light of the results mentioned in this section, it certainly cannot be excluded that in this aminodehydrogenation an SN(ANRORC) mechanism is (partly) involved in the formation of these products.