By Marcelino Cereijido, James M. Anderson
Because the first certain evaluation of the topic, Tight Junctions introduced jointly various views from best investigators to supply a multidisciplinary evaluation of the sector. when you consider that its e-book in 1992, there was an explosion of data approximately tight junctions, relatively within the quarter of molecular constitution, mobilephone and molecular biology, genetics and body structure. the sector has complex so speedy and thus far that it impacts many parts of biology and now has functional implications for pharmacology of drug supply and realizing a variety of illnesses changing epithelial permeability.
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Additional resources for Tight Junctions
124, 949–961. Jou, T. , Schneeberger, E. , and Nelson, W. J. 1998. Structural and functional regulation of tight junctions by RhoA and Rac1 small GTPases. J. , 142, 101–115. Keon, B. , and Franke, W. W. 1996. Symplekin, a novel type of tight junction plaque protein. J. , 134, 1003–1018. , and Tsukita, S. 1999. Ca2+-independent cell-adhesion activity of claudins, a family of integral membrane proteins localized at tight junctions. Curr. , 9, 1035–1038. , Swaisgood, M. , Ramos, B. , and Steck, T.
J. Biol. , 275, 20520–20526. , Jesaitis, L. , Gallin, W. , Goodenough, D. , and Stevenson, B. R. 1996. The tight junction protein ZO-2 contains three PDZ (PSD-95/Discs-Large/ZO-1) domains and an alternatively spliced region. J. Biol. , 271, 25723–25726. Bevers, E. , Dekkers, D. , and Zwaal, R. F. 1999. Lipid translocation across the plasma membrane of mammalian cells. Biochim. Biophys. Acta, 1439, 317–330. Bizzozero, T. 1870. Osservazion: sulla struttura degli epitheli pavimentosi stratificati.
Recent studies suggest that other TJ plaque proteins may contribute to the regulation of cell growth and differentiation by participating in the transduction of signals from the surface of the cell to the nucleus (Balda and Matter, 2000). 1 TJ-Associated Cytoplasmic Proteins Protein ZO-1 ZO-2 Properties MAGUKa (Nucleus and TJ) MAGUK ZO-3 Cingulin Symplekin 7H6 AF6 ASIP MAGUK Phosphoprotein Nucleus and TJ of epithelia Phosphoprotein Ras interacting protein Atypical PKCb iso-type-specific interacting protein Vesicle targeting protein Vesicle targeting protein Serine kinase ErbB-2 transcription factor Monomeric GTPase Monomeric GTPase Heterotrimeric G protein Protein kinase Sec6/8 VAP-33 ZAK ZONAB Rab 3B Rab 13 Gαi2 PKC a b Ref.